Respiration must be available (see section 4.4). The product must only be used by physicians trained in endotracheal intubation. Intravenously 1-2 min before the injection of Etomidate-Lipuro 2 mg/ml (see section 4.4 and 5.1). Since etomidate has no analgesic effect, it is recommended to administer a suitable opioid, e.g. Spontaneous muscle movements (myoclonus) shown by some patients after Etomidate-Lipuro 2 mg/mlĪdministration (see section 4.4 and 5.1).
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The use of narcotic analgesics or diazepam as premedication and during surgery will reduce the uncontrolled Paravenous injection causes severe local pain. Intra-arterial injection must be avoided. Resumed 24 hours after administration breast milk secreted during this period must be discarded.Įtomidate-Lipuro 2 mg/ml must be injected strictly intravenously and slowly, usually over approximately If Etomidate-Lipuro 2 mg/ml must be given during the lactation period, nursing is to be interrupted and not to be Caution should be exercised when Etomidate-Lipuro 2 mg/ml is The decreased values remained within the normal range.Įtomidate is excreted into human milk.
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Have received etomidate are comparable with those of infants born after the use of other hypnotic agents.Ī transient fall in cortisol levels lasting about 6 hours was observed in the neonate after the mother was givenĮtomidate. The Apgar scores of the newborns whose mothers At maternally toxicĭoses in rats, decreased survival was noted.Įtomidate-Lipuro 2 mg/ml should be used during pregnancy only if the potential benefit justifies the risks to theĭuring obstetric anaesthesia, etomidate may cross the placenta. In animalsĮtomidate has no primary effect on fertility, nor primary embryotoxic nor teratogenic effects. Safety of the use of Etomidate-Lipuro 2 mg/ml during pregnancy has not yet been established. Caution should be used when both drugs are administered together as theĬoncentrations of etomidate may drop below the hypnotic threshold.Ĭalcium channel blockers (Verapamil, Diltiazem)Ĭombination with general anaesthetics results in an enhancement of the hypotensive effect and also AV delay.īecause of hazardous interactions between general anaesthetics and MAOIs, MAOIs should normally be stopped 2 May enhance the effect of other drugs reducing blood pressure.Ĭo-administration of etomidate with alfentanil has been reported to decrease the terminal half-life of etomidate Induction with etomidate may be accompanied by a slight and transient reduction in peripheral resistance which The hypnotic effect of etomidate may be enhanced by: Interactions with other medicinal products and other forms of interaction
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Normal dose for adults is sometimes necessary to obtain the same depth and duration of sleep as obtained in In children under 15 years the dosage may need to be increased: a supplementary dose of up to 30% of the Hypnosis can be prolonged by additional injections of Etomidate-Lipuro 2 mg/ml.ĭo not exceed the total amount of 3 ampoules (30 ml). Therefore, in an adult patient one ampoule usually suffices for a sleep duration of 4-5 min. The following dosage guidelines should be followed:Īs a rule, the effective hypnotic dose is 0.3 mg of etomidate per kg body weight, corresponding to 0.15 ml ofĮtomidate-Lipuro 2 mg/ml per kg body weight. In all patients, the dosage should be adjusted according to the individual response and the clinical effect. Older than 6 months, children and adolescents. One ampoule (10 ml) of emulsion for injection contains:įor the full list of excipients, see section 6.1.Įtomidate-Lipuro 2 mg/ml is indicated for the induction of general anaesthesia in adults, infants and toddlers 10 ml of emulsion for injection (= 1 ampoule) contain 20 mg of etomidate